| abstract |
The present invention relates to new heteroaromatic amine derivatives of the general formula in the n is the number 0 or 1, A is a methylene, carbonyl or thiocarbonyl group, B is a methylene, carbonyl or thiocarbonyl group, where only one of the radicals A or B can be a thiocarbonyl group and in this case the other of the radicals A or B must be a methylene group, E is a straight-chain alkylene group optionally substituted by an alkyl group, G is a straight-chain alkylene group optionally substituted by an alkyl group, R₁ and R₂, which may be the same or different, are hydrogen atoms, alkyl or alkoxy groups or R₁ and R₂ together are an alkylenedioxy group, R₃ is a hydrogen atom, an alkenyl group, an alkyl or phenylalkyl group and Het has a 5- or 6-membered heteroaromatic ring which is bonded via a carbon or nitrogen atom and which contains one oxygen, sulfur or nitrogen atom, two nitrogen atoms or one nitrogen atom and one oxygen or sulfur atom, to which a 1 is additionally attached via two adjacent carbon atoms , 3-propylene, 1,4-butylene or 1,4-buta-1,3-dienylene group can be bonded, in which case the bond can also take place via the carbon ring, and in which the carbon skeleton of the aromatic mentioned above and heteroaromatic rings through a halogen atom, an alkyl, hydroxy, alkoxy, phenylalkoxy, phenyl, dimethoxyphenyl, nitro, amino, acetylamino, carbamoylamino, N-alkyl-carbamoylamino, hydroxymethyl, mercapto , Alkylmercapto, alkylsulfinyl, alkylsulfonyl, alkylsulfonyloxy, alkylsulfonylamino, alkoxycarbonylmethoxy, carboxymethoxy or alkoxymethyl group mono- or disubstituted or by a methylenedioxy or ethylenedi oxy group can be substituted and at the same time an optionally present imino group in the heteroaromatic radicals mentioned above can be substituted by an alkyl, phenylalkyl or phenyl group, mean their N-oxides, their enantiomers, their diastereomers and their acid addition salts with inorganic or organic acids, which have valuable pharmacological properties, in particular a heart rate lowering and a positive inotropic effect.n n n The new compounds can be prepared by processes known per se. |