| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6cfc033f059d282fcd915bc8be2ae53f |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-0613
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A23L27-30 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-075
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A23L27-30 |
| filingDate |
1987-12-01^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_325ed28a54bee72b0ec2f41089b93d9d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fcefaaae9ddfb3ff5441f4f5daa138c6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_64a383624372693c949f566e372addf2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8a5413caefad16a0063267bf7cc51779
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b286a0a0f7c941fd0e588822fe5b97ac |
| publicationDate |
1988-06-08^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-0270345-A2 |
| titleOfInvention |
Preparation of alpha-L-aspartyl-L-phenyl-alanine methyl ester or hydrohalide thereof |
| abstract |
α-L-aspartyl-L-phenylalanine methyl ester or the hydrohalide thereof is prepared by esterifying α-L-aspartyl-L-phenylalanine or α-L-aspartyl-L-phenylalanine which has been formed in situ by treating an N-protected-α-L-aspartyl-L-phenylalanine in an aqueous solution of sulfuric acid or a methanol-containing aqueous solution of sulfuric acid in the presence of an alkali metal halide or alkaline earth metal halide in a medium composed of sulfuric acid, water and methanol, thereby to allow the resulting α-L-aspartyl-L-phenyl-alanine methyl ester to precipitate as its corresponding hydrohalide, and then isolating the hydrohalide; and when the preparation of the methyl ester is desired, neutralizing the hydrohalide. |
| priorityDate |
1986-12-05^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |