| abstract |
The present invention describes novel 2,4-disubstituted derivatives of tetrahydrofuran, having the formula I n wherein: n-X- is either an oxygen atom or a covalent single bond; -CH₂XR₁ group is in the position 2 and -CH₂OR₂ is in the position 4 of the tetrahydrofuran ring, or -CH₂XR₁ is in position 4 and -CH₂OR₂ in position 2; -R₁ represents an alkyl or an alkylaminocarbonyl group; -R₂ represents a group having the formula -Y-(CH₂ n -Q.(A⁻) q where -Y- is a covalent single bond, a carbonyl group, a carbonyloxy group or a carbonylamino group; n is an integer 0 to 10; Q is a nitrogen containing heterocycle; q is one when Q is charged or q zero when Q is neutral; and A⁻ is a pharmaceutically acceptable anion. These compounds are PAF antagonists and, thus, useful for the treatment of diseases in which PAF is involved. |