http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0342664-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_56666880a5e2b7703e98a4f9b2d9daf6 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D311-58 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D311-22 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D311-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D311-58 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-352 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-35 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-08 |
| filingDate | 1989-05-18^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5b36f037385323b68d5040f10958c8c8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9e2818ac26f3e2f1021d3cd524f5914d |
| publicationDate | 1989-11-23^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-0342664-A2 |
| titleOfInvention | 2,2-disubstituted benzopyran leukotriene-D4 antagonists |
| abstract | This invention relates to 2,2-di-substituted benzopyran compounds which possess leukotriene-D 4 (LTD 4 ) antagonistic activity. In particular this invention relates to LTD 4 antagonists of the formula:n or a pharmaceutically acceptable addition salt thereof,n wherein R 1 is methyl, phenyl,n n wherein X 1 and X 2 may be the same or different and are members of the group comprising hydrogen, -Cl, -Br, -CF 3 , -NH 2 , -N0 2 , or straight or branched chain alkyl of 1-3 carbon atoms; wherein m is an integer from 1-9; wherein n is an integer from 1-5; . wherein V is C=O, -CH(OH)-, or -CH 2 -; wherein W is hydrogen or straight or branched chain alkyl of 1-6 carbon atoms; wherein Y is hydrogen or -COCH 3 ; wherein Z is -CHO, -COOR 2 , -COR 3 ,n or -CH 2 OR 4 ; wherein R 2 is hydrogen, a pharmaceutically acceptable cation, straight or branched chain alkyl having 1-6 carbon atoms,n or -CH(CH 2 OR 5 ) 2 with the proviso that when Z is -COOR 2 , the R 2 substituent in one -COOR 2 moiety may be the same or different from the R 2 substituent in the other COOR 2 moiety; wherein R 3 isn and wherein R 7 and R 8 may be the same or different and are members of the group comprising hydrogen or straight or branched chain alkyl having 1-6 carbon atoms; or wherein N, R 7 , and R 8 may together form a cyclic amine of the formulan wherein p is 4 or 5; wherein R 4 is hydrogen, orn wherein R 5 is hydrogen, benzyl-, or straight or branched chain alkyl having 1-3 carbon atoms; and wherein R 6 is straight or branched chain alkyl of 1-6 carbon atoms. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/FR-2673629-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0504017-A1 |
| priorityDate | 1988-05-20^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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