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filingDate 1989-06-23^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5b2d52375843179408151bde52f8e494
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publicationDate 1989-12-27^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-0348212-A2
titleOfInvention Method for determining susceptibility of an organism to a potentially toxic agent
abstract A method for determining the susceptibility of an organism to a potentially toxic agent comprising: (i) providing a control sample and a treatment sample from cells derived from the organism; (ii) contacting the treatment sample with the potentially toxic agent; (iii) incubating the cells of the treatment and control samples after step (ii), in nutrient medium and then assaying the apparent number of intact cells; and, (iv) determining a measure of susceptibility of the organism to the potentially toxic agent from a comparison of the change in number of apparently intact cells in the control and treatment samples over time. This method can be used to assess the therapeutic regime to give maximum benefit with minimum risk. It can be also used to test applicants for employment where there is an occupational hazard associated with genetoxic agents.
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