| abstract |
Compounds of general formula In wherein: nX represents oxygen or sulphur; neach of R¹ and R³ independently represents hydrogen or a C₁-C₄ alkyl group; nAr represents: na phenyl ring optionally substituted by one, two or three C₁-C₄ alkoxy groups and/or by one or two halogen atoms; na phenyl ring of the general formulan wherein R² represents halogen, 4,5-benzo, C₁-C₈ alkoxy, C₁-C₄ alkylcarbonyl or Am, wherein Am represents amino, methylamino or dimethylamino, n R⁴ represents C₁-C₈ alkyl, nn is 1 or 2; or na pyrimidinyl moiety of the general formulan wherein R⁵ is C₁-C₄ alkyl; nand their N-oxides and pharmaceutically acceptable salts are useful as antischizophrenic and/or antipsychotic agents. A preferred compound is S (-)-4-amino-N-(1-azabicyclo[2.2.2]-oct-3-yl)-5-chloro-2-methoxybenzamide. |