| abstract |
N-sulfamyl-propionamidine derivatives are prepared by the reaction of 3-substituted-propionitriles with an oxonium hydrochloride, preferably of 1,4-dioxane, in the presence of sulfamide in a close system at pressures between 0.5 kg/cm and 4.0 kg/cm. These compounds are useful in the preparation of famotidine, an anti-ulcer agent. |