| abstract |
Analogs of 2-aryl-5-3-Methoxy-5-(2-hydroxypropylsulfonyl)-4-propoxyphenyl)tetrahydrothiophene were prepared. n These compounds are found to be leukotriene inhibitors and potent and specific PAF (Platelet Activating Factor) antagonists. They are therefore useful in the treatment of various diseases or disorders mediated by the leukotriene and/or PAF, for example, inflammation, cardiovascular disorder, asthma, lung edema, adult respiratory distress syndrome, pain, and aggregation of platelets. |