| abstract |
Novel 2-aminopyrimidinone derivatives of formulan wherein n-A¹=A²-A³=A⁴- is -CH=CH-CH=CH-, -N=CH-CH=CH-, -CH=N-CH=CH-, -CH=CH-N=CH-, -CH=CH-CH=N-, -N=CH-N=CH-, -CH=N-CH=N-; nB is NR⁸, CH₂, O, S, SO or SO₂; R⁸ is hydrogen, C₁₋₆alkyl, C₃₋₆cycloalkyl, C₁₋₆alkylcarbonyl, C₁₋₆alkyloxycarbonyl or Ar²-C₁₋₆alkyl; nR¹ is hydrogen, C₁₋₁₀alkyl, C₃₋₆cycloalkyl, Ar¹, mono- and di(Ar¹)-C₁₋₆alkyl, or a radical -Alk-G-R⁷; nR², R³ are hydrogen or C₁₋₆alkyl; nR⁴ is hydrogen, C₁₋₆alkyl optionally substituted with Ar², pyridinyl, furanyl, 5-methyl-2-furanyl or C₁₋₆alkyloxy; nR⁵ is hydrogen, C₁₋₆alkyl, C₁₋₆alkylaminocarbonyl or Ar²-aminocarbonyl; nR⁶ is hydrogen or C₁₋₆alkyl; or R⁵ and R⁶ taken together may form a bivalent radical of formula -CH₂-CH₂-, -CH₂-CH₂-CH₂-, -CH=CH-, -CH=N-, -N=CH-, -N=CH-CH₂-; nn is 0, 1 or 2; nthe pharmaceutically acceptable acid addition salts and possible stereochemically isomeric forms thereof; pharmaceutical compositions containing such compounds as an active ingredient and methods of preparing said compounds and pharmaceutical compositions. |