http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0393045-A1

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filingDate 1988-09-09^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_62bac2c7d7287ec8f7915cd57d39c843
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publicationDate 1990-10-24^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-0393045-A1
titleOfInvention Fv antibody fragment production
abstract A process for the production of a polypeptide comprising direct expression of the polypeptide in bacterial host cells characterised in that an inducible expression system is used in combination with a protease deficient bacterial host system. The process is particularly useful for the production of small polypeptides especially immunologically functional antibody fragments and in particular heavy and light chain polypeptides comprising complementary variable domains. Further aspects of the invention relate to suitable expression vectors and bacterial host systems.
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priorityDate 1987-09-09^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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