| abstract |
A process for producing the compound [2S-(2α,3β,5α)]-3-methyl-7-oxo-3-(1 H -1,2,3-triazol-1-ylmethyl)-4-thia-azabicyclo[3 2 0]-heptane-2-carboxylic acid, (4-nitrophenyl)methyl ester, 4,4-dioxide, which comprises reacting a solution of azidopenamsulfone, 4-methoxyphenol and vinylpropionate with a solution of bis(trimethylsilyl)acetamide and 4-methoxyphenol in toluene at 80-100°C for 18-30 hours followed by filtering the resulting solution and cooling the filtrate to 0-10°C. |