| abstract |
New nonionic radiographic contrast agents having the formula <CHEM> wherein Y is a single bond -CH2CH2-, -CH2O-, -OCH2-, <CHEM> R1 and R2 are the same or different and are <CHEM> <CHEM> R3 and R4 are the same or different and are hydrogen, methyl or -CH2CH2OH; R5 is hydrogen, alkyl, -CH2CH2OH, CH2OH or OH and R6 is alkyl, -CH2CH2OH, CH2OH, OH or hydrogen and may be the same or different than R5 and m is zero or one with the proviso that no methylene or methine carbon atom of the heterocyclic ring is attached to both a nitrogen and an oxygen atom with the additional proviso that when Y is a single bond then m is not zero. These new contrast agents are water soluble and have desirable low osmolality properties. |