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filingDate 1992-05-26^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c7f28c875ce2945b47a17ef074a1cc46
publicationDate 1992-12-09^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-0517412-A1
titleOfInvention Pharmaceutical formulations of a benzodiazepine
abstract Pharmaceutical formulations comprising 3R(+)-N-(2,3-dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl)-N'-(3-methylphenyl)-urea and a pharmaceutically acceptable carrier, characterised in that the carrier comprises a pharmaceutically acceptable oil selected from esterification or polyether products of glycerides with vegetable oil fatty acids of chain length C₈-C₁₀ and a pharmaceutically acceptable surfactant selected from oleate and laurate esters of a polyalcohol copolymerised with ethylene oxide are disclosed. They optionally also contain a plasticiser and/or water and/or α-D-tocopherol. Preferably, the formulations are prepared by known methods and are filled into hard or soft gelatin capsules. The formulations are useful for the treatment or prevention of medical conditions in which an excess of CCK is implicated such as pain, panic or anxiety.
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