| abstract |
Compounds of formula (I), and salts and prodrugs thereofn n wherein n n is 1, 2 or 3; n X represents O or S; n R¹ represents optionally substituted phenyl; n R² represents aryl, heteroaryl, benzhydryl, or benzyl; n R⁴ and R⁵ each independently represent H, halo, CH₂OR⁹, C₁₋₆alkyl, oxo, CO₂R¹⁰ or CONR¹⁰R¹¹; n R⁸ represents H, COR⁹, CO₂R¹⁰ or optionally substituted C₁₋₆alkyl; n R⁹ represents H, C₁₋₆alkyl or phenyl; and n R¹⁰ and R¹¹ each independently represent H or C₁₋₆alkyl; are tachykinin antagonists. They and compositions thereof are useful in medicine. |