http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0634415-A2

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filingDate 1994-07-14^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_356553fa73049c5e44e4d9f7df5b9a32
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fcb142bcea5ae883356b016617eda596
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publicationDate 1995-01-18^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-0634415-A2
titleOfInvention Cephem compound, its production and its use for producing cephem antibiotics
abstract A 3-[(E)-1-propenyl]cephem derivative represented by formula (I) :n nwherein R represents hydrogen, an amino protecting group or a group of formula (II) :n nin which R 3 is an amino protecting group, R 4 is a hydroxy protecting group, and W is -CH= or -N=, R 2 represent a carboxy protecting group and X represents hydrogen or chlorine ; or a salt thereof ; may be prepared by isomerizing the corresponding 3-[(Z)-1-propenyl]cephem compound in an inert organic solvent in the presence of an aromatic thiol. These compounds are useful as intermediates for cephem antibiotics. A compound of formula (I) wherein X is chlorine can be converted into a 3-[(E)-3- ammonio-1-propenyl]cephem derivative by reaction with a tertiary amine.
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