| abstract |
A serine derivative represented by general formula (I) or a pharmaceutically acceptable salt thereof, having an anti-PCP(phencyclidine) activity and being useful as a psychotropic, wherein X represents sulfur or oxygen; Y represents nitrogen or CH; R¹ and R² represent each independently hydrogen, lower alkyl or an amino-protecting group, or R¹ and R² may be combined together to form 4- to 9-membered nitrogenous cycloalkyl; R³ represents hydrogen, carboxy, protected carboxy, aralkyl, or lower alkyl which may be hydroxylated; R⁴ represents hydrogen or hydroxy; R⁵ represents hydrogen or lower alkyl; A represents lower alkylene; B represents (1) an (un)saturated 4-to 10-membered nitrogenous cycloalkyl group which may be substituted by lower alkyl or aralkyl, or (2) a bicyclic nitrogenous hydrocarbon ring group comprising a 4- to 8-membered nitrogenous cycloalkyl group and a benzene ring fused together; and ... represents a single or a double bond. |