| abstract |
A 3-aminoazepine compound represented by general formula (I), an optically active isomer thereof, or a pharmaceutically acceptable salt thereof, wherein Ar represents phenyl, etc.; R¹ represents hydrogen, alkyl, etc.; R² and R³ represent each independently hydrogen, alkyl, -CO-R⁶ (wherein R⁶ represents heteroaryl, etc.), -CONH-R⁷ (wherein R⁷ represents phenyl, etc.), etc.; R⁴ represents hydrogen, alkyl, etc.; X represents oxygen or sulfur, provided R⁴ and X may be combined together to form -C(R¹⁰)=N-N= (wherein R¹⁰ represents hydrogen, alkyl, etc.). This compound has CCK and gastrin antagonisms and is useful as a remedy for central nervous system diseases such as anxiety and depression and as a preventive or a remedy for pancreatic diseases and gastrointestinal ulcer. |