| abstract |
The present invention relates to improved methods for the selection of recombinant host cells expressing high levels of a desired protein, which methods are useful with a wide variety of eukaryotic host cells and avoid the problems inherent in existing cell selection technology. The invention further relates to intron-modified selectable genes, comprising the coding sequence of a selectable gene and an intron that reduces the level of selectable protein produced from the selectable gene in a host cell, which are useful in the methods of the invention. |