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filingDate 1994-09-02^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2003-08-13^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1455b043e78b40e1afb0ed264136d299
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4a4a1b2c0511298eab681130249b1ca3
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publicationDate 2003-08-13^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-0728139-B1
titleOfInvention Amine-derivatized nucleosides and oligonucleosides
abstract Oligonucleotide-folate conjugates are described wherein folates are conjugated to one or more sites on an oligonucleotide including the 2'-, 3'-, 5'-, nucleobase and internucleotide linkage sites. The folate can be attached via the alpha- or gamma-carboxylate, optionally through a linking group. Methods for the regiospecific synthesis of the conjugates are disclosed.
priorityDate 1993-09-03^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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