| abstract |
The present invention relates to compounds of formula I and II;n n whereinn X is -O-, -S-, or -NR 5 -; Y is -O-, -S-, -CH 2 -, -CH 2 CH 2 -, -CH=CH-, or -NR 5 -; B is -CH 2 - or -CO-; R 1 , R 2 , and R 3 are each independently -H, -OH, -O(C 1 -C 4 alkyl), -OCOC 6 H 5 , -OCO(C 1 -C 6 alkyl), -OSO 2 (C 4 -C 6 alkyl), -OSO 2 CF 3 , Cl, or F; n is 1 or 2; W is CH 2 or C=O; R 4 is 1-piperidinyl, 2-oxo-1-piperidinyl, 1-pyrrolidinyl, methyl-1-pyrrolidinyl, dimethyl-1-pyrrolidinyl, 2-oxo-1-pyrrolidinyl, 4-morpholino, dimethylamino, diethylamino, or 1-hexamethyleneimino; R 5 is C 1 -C 3 alkyl, -COC 6 H 5 , -CO(C 1 -C 6 alkyl), -C(O)OC 6 H 5 , -C(O)O(C 1 -C 6 alkyl), -SO 2 (C 1 -C 6 alkyl), -SO 2 C 6 H 5 , or -SO 2 CF 3 ; or a pharmaceutically acceptable salt thereof.n Also provided by the present invention are intermediate compounds; processes for the preparation of compounds of Formulae I and II; and pharmaceutical methods and formulations employing the compounds of Formulae I and II. |