| abstract |
The use of a compound of the formula In or a pharmaceutically acceptable acid addition salt thereof, whereinn R 3 is 1-piperidyl, 1-(3-indolyl)ethyl, (C 1 -C 4 )-alkyl, phenyl, benzyl, 1-(1-phenylethyl) or monosubstituted benzyl wherein the substituent is chloro, fluoro, methyl or methoxy and said substituent is on the aromatic ring; R 4 is bicyclo[2.2.1]hept-2-yl or a group of the formula IIn wherein Y is hydrogen, fluoro or chloro; and X is hydrogen, fluoro, chloro, methoxy, trifluoromethyl, cyano, carboxy, methylcarbamoyl, dimethyl-carbamoyl or carbo(C 1 -C 4 )alkoxy; for the manufacture of a medicament for inhibiting phosphodiesterase (PDE) type IV or the production of tumor necrosis factor (TNF). |