http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0828847-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7deec310bcff1dbb86e20facdebebe33 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f07ba5e7ff356b7eda43fdfc20eef4b0 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P21-02 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-76 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-96 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P1-00 |
| filingDate | 1996-06-03^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a3c7a0cac0efd73426586715b88bc2cd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a3280efa8daa68ef38fe4724181e3a52 |
| publicationDate | 1998-03-18^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-0828847-A1 |
| titleOfInvention | Enzyme catalysis in organic solutions |
| abstract | Organic enzyme solutions include an ion pair complex of an enzyme and a surfactant, and an organic solvent in which the enzyme-surfactant ion pair is dissolved, the solution having catalytic activity at least an order of magnitude greater than a suspension of an equal amount of the enzyme and organic solvent without ion pair complexes. The enzyme is preferably a hydrolase with an acyl transferase activity and the surfactant is Aerosol OT (sodium bis(2-ethylhexyl) sulfosuccinate) at low concentrations. The organic enzyme solution may be made by obtaining an aqueous solution of an enzyme at a pH of maximal enzyme activity, adding an ionic surfactant to the aqueous solution in an amount sufficient to form an ion pair, and extracting the enzyme-surfactant ion pair into an organic solvent phase without substantial formation of reversed micelles, to produce an anhydrous organic enzyme solution comprising the enzyme-surfactant ion pair dissolved in the organic solvent such that the enzyme retains native structure and substantial catalytic activity. Catalytic solutions according to the invention can be used to catalyze peptide synthesis from acyl donors and nucleophiles. |
| priorityDate | 1995-06-01^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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