| abstract |
The present invention relates to an inhibitor for the production of 3-deoxyglucosonen(3-DG) which contains at least one of parabanic acid derivatives represented by the followingnformula (I) or pharmaceutically acceptable salts thereof as an effective ingredientn n wherein R is hydrogen or lower alkyl; X is hydrogen, alkyl, cycloalkyl, lowernalkylcycloalkyl, phenyl or phenylalkyl which is optionally substituted with lower alkyl, lowernalkoxy, nitro and/or halogen; and n is an integer of from 1 to 4. n The compound of the present invention has an action of inhibiting the production of 3-DGnwhich is a highly active intermediate and participates in a protein crosslinked formation innMaillard reaction and, therefore, said compound is useful in the treatment and the preventionnof various diseases induced by deposition into tissues or sclerosis or denaturation of crosslinkednprotein, similar diseases induced by aging and diabetic complications. |