| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_601b9290f70d8c03f8fc0073895618dc
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_fb77dad9281a6322c07147062b24c899 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y302-01018
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y302-01022
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-2402
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y302-01049
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y302-01045
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y302-01076
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-8257
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-8237
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y302-01024 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-82
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-43
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-24 |
| filingDate |
1996-09-13^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_24e78c1426009704d0e25c8957a9c3ab
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_99c4f58d8d5ed62886e4d9e26c0514bc
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_441f31312acb0862eec27282a6e18d48
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0956e2a8b5917cbdf6fe89da0ebde9e0 |
| publicationDate |
2004-06-16^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-0865499-A4 |
| titleOfInvention |
PRODUCTION OF LYSOSOMAL ENZYMES IN VEGETABLE EXPRESSION SYSTEMS |
| abstract |
The invention relates to the production of enzymatically active recombinant human and animal lysosomal enzymes involving construction and expression of recombinant expression constructs comprising coding sequences of human or animal lysosomal enzymes in a plant expression system. The plant expression system provides for post-translational modification and processing to produce a recombinant gene product exhibiting enzymatic activity. The invention is demonstrated by working examples in which transgenic tobacco plants having recombinant expression constructs comprising human hGC and IDUA nucleotide sequences produces enzymatically active modified human glucocerebrosidase and human α-L-iduronidase. The recombinant lysosomal enzymes produced in accordance with the invention may be used for a variety of purposes, including but not limited to enzyme replacement therapy for the therapeutic treatment of human and animal lysosomal storage diseases. |
| priorityDate |
1995-09-14^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |