| abstract |
A new process for the production of (1S, 4R) - or (1R, 4S) -4- (2-amino-6-chloro-9-H-purin-9-yl) -2-cyclopentene-1-methanol is described of the formulas n n n In the first stage, (±) -2-azabicyclo [2.2.1] hept-5-en-3-one of the formula to a (±) -2-azabicyclo [2.2.1] hept-5-en-3-one derivative of the general formula wherein R 1 is C 1-4 alkyl, C 1-4 alkoxy, aryl or aryloxy, acylated, this in the second stage to a cyclopentene derivative of the general formula in which R 1 has the meaning given, reduced this then in the third stage biotechnologically into (1R, 4S) - or (1S, 4R) -1-amino-4- (hydroxymethyl) -2-cyclopentene according to the formula implemented this in the fourth stage with N- (2-amino-4,6-dichloropyrimidine) -5-yl) formamide of the formula ins (1S, 4R) - or (1R, 4S) -4 - [(2-amino-6-chloro-5-formamido-4-pyrimidinyl) -amino] -2-cyclopentene-1-methanol of the formulas transferred and the latter in the fifth stage cyclized in a known manner to the end product according to formula I or II. |