http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0882020-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_84d9adaa7e7ce01ce8020f5c721aba10 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D217-20 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D217-20 |
| filingDate | 1997-02-12^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_150b4118452a738da424412d971c1e87 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_28f21e13af5a3d105f268c5906e94573 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6c5ae334b920cbd658c2897a95fc0407 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4c9542f464936d7f3f1d225a0e357ad6 |
| publicationDate | 1998-12-09^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-0882020-A1 |
| titleOfInvention | Process for the preparation and isolation of atracurium besylate |
| abstract | A process of producing atracurium besylate that substantially reduces the level of impurities in the final product and avoids the repeated use of ether is provided. In accordance with such a process, N, N'-4,10-dioxa-3,11-dioxotridecylene-1,13-bis-tetrahydropapaverine (Compound 1), methyl benzenesulfonate and a catalytic amount of an insoluble base in a solvent are combined to form a reaction mixture that is maintained for a period of time sufficient for atracurium besylate formation. The reaction mixture is then filtered to remove the insoluble base and the atracuriurn besylate is precipitated. |
| priorityDate | 1996-02-16^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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