| abstract |
New isoquinoline-3-carboxamides of the formula I in which R 1 is hydrogen or chlorine, R 2 is hydrogen, alkyl, alkoxy, chlorine, trifluoromethyl, hydroxy, or benzyloxy, which is optionally substituted, or fluoroalkoxy of the formula O- [CH 2 ] x -C f H (2f + 1- g) F g with x = 0 and 1, f = 1-5 and g = 1 to (2f + 1), R 3 is hydrogen, alkyl, alkoxy, fluorine, chlorine, cyano, trifluoromethyl, hydroxy, or benzyloxy, which is optionally substituted, or fluoroalkoxy of the above formula, R 4 and R 5 are hydrogen, alkyl, fluorine, chlorine, bromine, trifluoromethyl, cyano, alkoxy, or fluoroalkoxy of the above formula, including the physiologically active salts, are strong prolyl-4-hydroxylase Are inhibitors that do not cause steatosis. |