| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d202e9e866984fe229f6facc38f1d740 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-38 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-38
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-30 |
| filingDate |
1997-05-05^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_909734e4bab163dd0470d7cfe87616fd
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_17db1dc4fb6586f71c887af38eda3470
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_35a9d284057327c75c09277712c79f80
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f7b68186a3946122e522b9e31c19ab18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_853a8baf490c0473bdf9cc92d70abfb8 |
| publicationDate |
1999-05-06^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-0912517-A1 |
| titleOfInvention |
Method of preparing phosphodiesterase iv inhibitors |
| abstract |
A process for the preparation of Phosphodiesterase IV inhibitors of structural formula VIII, wherein R' is (substituted) phenyl, is described. The process consists of eight chemical steps involving five isolations to prepare the title compound from readily available isovanillin in 35 % overall yield (Scheme 1). The process is highlighted by: a) a highly diastereoselective Michael addition of phenyllithium using (1R, 2S) cis-aminoindanol as a chiral auxiliary, b) highly crystalline intermediates providing for efficient purifications, c) crystallization of the final compound as its CSA salt for excellent enantiomeric purity. |
| priorityDate |
1996-05-08^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |