| abstract |
N-(N'-substituted glycyl)-2-cyanopyrrolidines, e.g. the compounds of formula (I) wherein R has various significances, are novel. They inhibit DPP-IV (dipeptidyl-peptidase-IV) activity. They are therefore indicated for use as pharmaceuticals in inhibiting DPP-IV and in the treatment of conditions mediated by DPP-IV, such as non-insulin-dependent diabetes mellitus, arthritis, obesity, osteoporosis and further conditions of impaired glucose tolerance. |