| abstract |
Substituted piperidine derivatives of structural formula (I), wherein R1 represents a hydrogen atom or a methyl or trifluoromethyl group; R2 represents a hydrogen or halogen atom; and R3 represents a hydrogen or halogen atom; and pharmaceutically acceptable salts thereof are tachykinin receptor antagonists of use, for example, in the treatment or prevention of pain, inflammation, migraine, emesis, postherpetic neuralgia, depression and anxiety. |