| abstract |
The invention relates to medical treatments and compositions to prevent or reduce the occurrence of adhesions to and between body organs, parts of body organs and/or tissues in animals, in particular human beings, such as the adhesions occurring after surgical proccedures. The invention provides for reducing or preventing adhesions to or between organs, parts of organs or tissues, at a particular location, in an animal, comprising subjecting said animal to a treatment which provides for increased synthesis and/or secretion of plasminogen activator by mesothelial cells present at said location, or to a treatment which provides for decreased synthesis and/or secretion of plasminogen activator inhibitor by mesothelial cells present at said location. The active agents are selelcted form the group composed of vastatins or distinct natural oxysterols, such as 22 (R)-hydroxycholesterol, mevalonate, or geranylgeraniol or combinations thereof, optionally combined with retinoic acid. |