| abstract |
This invention provides a quinolone derivative whichnexerts strong antibacterial action upon various bacteria and hasnhigh safety, and it relates to a compound having a structure ofnformula (I), its salts and hydrates thereof:n n{R 1 and R 2 : hydrogen, alkyl; n: 1 to 4; Q: following structuren(Ia):n n[R 3 : alkyl, alkenyl, halogenoalkyl, cyclic alkyl, aryl,nheteroaryl, alkoxyl, alkylamino; R 4 : hydrogen, alkylthio; R 5 :nhydrogen, amino, hydroxyl, thiol, halogenomethyl, alkyl, alkenyl,nalkynyl, alkoxyl; X 1 : halogen, hydrogen, A 1 : nitrogen, structurenof formula (II):n n(X 2 : hydrogen, amino, halogen, cyano, halogenomethyl, nhalogenomethoxyl, alkyl, alkenyl, alkynyl, alkoxyl; R 4 and R 3 ornX 2 and R 3 may together form a cyclic structure; Y: hydrogen,nvarious ester forming groups]}. |