| abstract |
The invention concerns a compound of general formula (I) wherein: R1 represents an alkyl, alkenyl or alkynyl chain, or a cycloalkyl, or (cycloalkyl)alkyl group substituted by at least a COOH, SO3H, PO3H2 or tetrazolyl group; R2 represents an alkyl chain, or an aryl, arylalkyl, cycloalkyl, (cycloalkyl)alkyl, (heteroaryl)alkyl group substituted or not by at least a OH, OR, SR', NH2, NHR', guanidinyl, COOH, CONH2 group, or a halogen atom; R3 represents a hydrogen atom or a methyl group; R4 represents a) an alkyl chain, an aryl, alrylalkyl, cycloalkyl, (cycloalkyl)alkyl, (heteroalkyl)alkyl, heterocycloalkyl or (heterocycloalkyl)alkyl group substituted by at least a CONH2, SO3H, SO2NH2, PO3H2 or tetrazolyl group, (b) C2-C6 alkyl chain, an aryl, arylakyl, cycloalkyl, (cycloalkyl)alkyl, (heteroaryl)alkyl, heterocycloalkyl, (heterocycloalkyl)alkyl group substituted by at least a CO2H group capable of being protected as described above; or c) R3 and R4 can together form a heterocyclic compound, with 5 to 6 links, substituted by at least a CO2H, CONH2, SO3H, SO2NH2 or PO3H2 group; X represents a CONH or CH2NH; and Z represents a OH, OCH2-C6H5 or NR''R''' group. |