| abstract |
Aminobutylic acid derivatives of the formula (I) :n nwherein the symbols are as defined in specification; andnnon-toxic salts thereof. Because of inhibiting matrixnmetalloproteinase, the compounds of the formula (I) are usefulnfor prevention and/or treatment of diseases, for example,nrheumatoid diseases, arthrosteitis, osteoarthritis, unusualnbone resorption, osteoporosis, periodontitis, interstitialnnephritis, arteriosclerosis, pulmonary emphysema, cirrhosis,ncornea injury, cornea ulcer, metastasis, invasion or growth ofntumor cells, autoimmune disease, disease caused by vascularnemigration or infiltration of leukocytes, arterialization,nmultiple sclerosis, arota aneurysm, endometriosis, restenosisnafter PTCA, unstable angina, acute myocardial infarction,ntransient ischemic attack. |