http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1186306-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5d5bb9b9a6d998b72b154ceb1895a3f5 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-0491 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K51-04 |
| filingDate | 2000-09-05^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_978ad57bdac667382d018f268e62e55f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c1941d58a52b5223db6c0b496cc7635c |
| publicationDate | 2002-03-13^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-1186306-A1 |
| titleOfInvention | Labeled nucleosides and method for their preparation |
| abstract | The invention relates to a method for the chemical preparation of labeled nucleosides via annoxidative-ring-opening step and a reductive-ring-closure step starting from a labeled D-glucosennucleoside resulting in the corresponding D-ribose-nucleoside by removing the carbon atom 3 onnthe glucose and comprising the steps of:n 1. a protection of the sugar ring hydroxyl groups, 2. a sugar-base condensation, whereby the base is a purine or a pyrimidine, 3. a deprotection of the sugar ring hydroxyl groups, 4. an oxidative-ring-opening and removal of the carbon atom 3, and 5. a reductive-ring-closure resulting in labeled D-ribose-nucleoside. n The invention further relates to a compound obtainable via the method according to theninvention having the formula selected from [ 13 C, 15 N] labeled 6'-O-mono- or 6'-O-bis-C 1 -C 6 -alkyloxytrityl-D-glycopyranosylnnucleosides, or [ 13 C, 15 N] labeled tetra-O-acetyl-D-glycopyranosylnnucleosides or [ 13 C, 15 N] labeled glycopyranosyl nucleosides. |
| priorityDate | 2000-09-05^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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