| abstract |
A class of substituted isoxazolyl compounds is described fornuse in treating inflammation and inflammation-related disorders.nCompounds of particular interest are defined by Formulan(III) wherein R 7 is selected from hydroxyl, lower alkyl, carboxyl,nhalo, lower carboxylalkyl, lower alkoxycarbonylalkyl,nlower alkoxyalkyl, lower carboxyalkoxyalkyl, lower haloalkyl,nlower haloalkylsulfonyloxy, lower hydroxyalkyl, lower aryln(hydroxylalkyl), lower carboxyaryloxyalkyl, lower alkoxycarbonylaryloxyalkyl,nlower cycloalkyl, lower cycloalkylalkyl,nand lower aralkyl; and wherein R 8 is one or more radicals independentlynselected from hydrido, lower alkylsulfinyl, lowernalkyl, cyano, carboxyl, lower alkoxycarbonyl, lower haloalkyl,nhydroxyl, lower hydroxyalkyl, lower haloalkoxy, amino, lowernalkylamino, lower arylamino, lower aminoalkyl, nitro, halo,nlower alkoxy, aminosulfonyl, and lower alkylthio; or a pharmaceutically-acceptablensalt thereof. |