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filingDate 2000-11-30^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9601ecca8014c70f65b7843cf07f6e80
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8a3bcc8f49814b470ba41c8c013e4c90
publicationDate 2002-08-28^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-1233828-A2
titleOfInvention Chiral catalysts for asymmetric acylation and related transformations
abstract A chiral catalyst comprising a 3, 4-disubstituted pyridine, or a salt, N functionalised derivative, dimer or oligomer thereof, wherein the 3-substituent is substantially hindered from rotation about the bond (sp<SUP>2</SUP>-sp<SUP>2 </SUP>biaryl axis) linking it to pyridine and the 4-substituent is an aliphatic or aromatic amine linked by a single bond to the pyridine, the pyridine nitrogen being functionalised or unfunctionalised, preferably comprising a compound of formula I wherein Z is a group substantially hindered from rotation about its bond; and each of R<SUP>1 </SUP>and R<SUP>2 </SUP>are independently selected from C<SUB>1-30 </SUB>alkyl, C<SUB>3-30 </SUB>cyclo alkyl and/or C<SUB>3-30 </SUB>aryl, or NR<SUP>1 </SUP>R<SUP>2 </SUP>form a cyclic amine; wherein R<SUP>1 </SUP>and/or R<SUP>2 </SUP>may be optionally substituted and/or include one or more heteroatoms; a composition or support comprising the catalyst; process for the preparation and resolution thereof; process for stereoselective reaction of an optically inactive substrate using the catalyst; and the optically active reaction product thereof.
priorityDate 1999-11-30^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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