| abstract |
The invention relates to substituted norbornylamino derivatives containing exo-configured nitrogen and an endo-annellated pentacyclic ring of formula (I) and exo-configured nitrogen and an exo-annellated pentacyclic ring of formula (Ia), wherein R1, R2 R3, R4, R5, A, B, S1 and S2 have the meanings cited in the claims. Said derivatives are especially suitable as anti-hypertensive agents for reducing or preventing ischaemia-induced damage, as medicaments for use in surgical procedures for treating ischaemias of the nervous system, of a cerebrovascular accident and of a cerebral oedema. The derivatives are also suitable for treating shock, an impaired respiratory impulse, snoring, or for use as a laxative, as an agent against ectoparasites, in the prophylaxis of gall stones, as an anti-atherosclerotic agent, as an agent for treating late complications of diabetes, or for treating cancerous illnesses, fibrotic disorders, endothelial dysfunction and organ hypertrophies and hyperplasias. Said derivatives act as inhibitors of the cellular sodium-proton-antiporter. They also influence serum lipoproteins and can thus be used in the prophylaxis and reversal of atherosclerotic changes. |