| abstract |
The mechanism by which pleiotrophin binds to the receptor protein tyrosine phosphatase β/z (RPTP β/z) is disclosed along with methods of modulating both pleiotrophin expression and signaling to treat, prevent and inhibit abnormal cell growth states. Specifically provided are methods of inhibiting tumor growth, promotion, metastasis, invasiveness and angiogenesis as well as methods of preventing or inhibiting cell adhesion. |