| abstract |
The invention relates to a compound of the formulan nwherein R 1 and R 2 are as defined in the description, useful in the treatment and conditionnselected from the group consisting of meningitis and salpingitis, septic shock, disseminatednintravascular coagulation, and/or adult respiratory distress syndrome, acute or chronicninflammation, arthritis, cholangitis, colitis, encephalitis, endocarditis, glomerulonephritis,nhepatitis, myocarditis, pancreatitis, pericarditis, reperfusion injury, vasculitis, acute and delayednhypersensitivity, graft rejection, and graft-versus-host disease, auto-immune diseases includingnType 1 diabetes mellitus and multiple sclerosis, periodonate diseases, interstitial pulmonarynfibrosis, cirrhosis, systemic sclerosis, keloid formation, tumors which produce IL-1 as annautocrine growth factor, cachexia, Alzheimers disease, percussion injury, depression,natherosclerosis (including cardiomyopathy, myocarditis and heart failure) and osteoporosis in anmammal, including a human. |