http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1272206-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_635f1533d3d426fad2b7e06ee37d1a27 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0527dad21ab86c8496273f9f77eacf85 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P5-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P5-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-575 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-30 |
| filingDate | 2000-09-26^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_eaa1a78c0036b2a5f4d8dffde238118a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6a54d5341bb71452e984c407eb865244 |
| publicationDate | 2003-01-08^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-1272206-A1 |
| titleOfInvention | Non-mammalian gnrh analogs and uses thereof in tumor cell growth regulation and cancer therapy |
| abstract | Specially designed non-mammalian GnRH analogs resistant to degradation by the tumor tissue enzymes, post-proline peptidases as well as endopeptidases, are disclosed. The GnRH analogs are further defined as analogs of chicken II GnRH, salmon GnRH, or herring GnRH, but can include any non-mammalian GnRH analog with similar amino acid structure. These non-mammalian analogs incorporate D-arginine, D-leucine- D-t-Bu-Serine ore D-Trp or other similar amino acids at position 6 and ethylamide or aza-Gly-amine or similar amides at position 10. These analogs demonstrate preferential binding to tumor cell GnRH receptors that is greater relative to the binding of the mammalian analogs to the tumor cell GnRH receptor. These non-mammalian GnRH analogs may be used in pharmaceutical preparations, and specifically in various treatments as an anti-tumor, anti-proliferation, anti-metastatic and/or apoptotic agent. The non-mammalian GnRH analogs are also provided in pharmaceutical preparations that may be used clinically for tumor regression when used in very low doses and administered in pulsatile fashion. |
| priorityDate | 2000-03-31^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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