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filingDate 2001-05-16^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cb97f36cdd1932cb8c9601556d00d0b4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b188f9731b90b5e964580bb73e8a7807
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publicationDate 2003-03-05^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-1286706-A2
titleOfInvention Gamma irradiation of protein-based pharmaceutical products
abstract Methods are disclosed for inactivation of microbial contaminants in proteinaceous materials while preserving the activity of the materials. The proteinaceous material is exposed to gamma radiation at a high dose rate (e.g., ⊃ 3 kiloGray/hour) while in a lyophilized state under conditions which preserve activity of the material. The material may be formulated to contain one or more stabilizers, and/or be lyophlized to a low moisture content (e.g., less than 1.5%) prior to exposure to the gamma radiation.
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