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filingDate 1998-11-17^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_95ff6ff9b6eabb7c2719e8a9ba350459
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publicationDate 2003-05-07^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-1308444-A1
titleOfInvention Substituted 2-(2,6-Dioxo-3-Fluoropiperidine-3-YL)-Isoindolines and their use to reduce TNF-alpha Levels
abstract 1-Oxo-2-(2,6-dioxo-3-fluoropiperidin-3-yl)-isoindolines and 1,3-dioxo-2-(2,6-dioxo-3-fluoropiperidin-3-yl)-isoindolinesnreduce the levels ofninflammatory cytokines such as TNFα in a mammal. A typicalnembodiment is 1,3-dioxo-2-(2,6-dioxo-3-fluoropiperidin-3-yl)-isoindoline.
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