| abstract |
This invention describes novel protein kinase inhibitors of formula (VII): wherein G is Ring C or Ring D; Ring C is selected from a phenyl, pyridinyl, pyrimidinyl, pyridazinyl, pyrazinyl, or 1,2,4-triazinyl ring, wherein said Rind C has one or two ortho substituents independently selected from -R1; Ring D is a 5-7 membered monocyclic ring or 8-10 membered bicyclic ring selected from aryl, heteroaryl, heterocyclyl or carbocyclyl; R?y is T-R3'¿; T is a valence bond or a C¿1-4? alkylidene chain; R?3'¿ is an optionally substituted group selected from C¿1-6? alphatic, C3-10 carbocyclyl, C6-10 aryl, a heteroaryl ring having 5-10 ring atoms; and R?1, R2, and R2'¿ are as described in the specification. The protein kinase are useful for treating diseases such as cancer, diabetes and Alzheimer's disease. |