| abstract |
The present invention concerns compounds of formula. In a preferable embodiment, X represents O; R1 represents C¿1-6?alkyl; cycloC3-12alkyl or (cycloC3-12alkyl)C1-6alkyl, wherein one or more hydrogen atoms in a C1-6alkyl-moiety or in a cycloC3-12alkyl-moiety optionally may be replaced by C1-6alkyloxy, aryl, halo or thienyl; R?2¿ represents hydrogen; halo; C¿1-6?alkyl or amino; R?3 and R4¿ each independently represent hydrogen or C¿1-6?alkyl; or R?2 and R3¿ may be taken together to form -R2-R3-, which represents a bivalent radical of formula -Z¿4?-CH2-CH2-CH2- or -Z4-CH2-CH2- with Z4 being O or NR?11¿ wherein R11 is C¿1-6?alkyl; and wherein each bivalent radical is optionally substituted with C1-6alkyl; or R?3 and R4¿ may be taken together to form a bivalent radical of formula -CH¿2?-CH2-CH2-CH2- ; R?5¿ represents hydrogen; Y represents O; and aryl represents phenyl optionally substituted with halo. The invention also relates to the use of a compound according to the invention as a medicament and in the manufacture of a medicament for treating or preventing glutamate-induced diseases of the central nervous system, as well as formulations comprising such a compound and processes for preparing such a compound. |