| abstract |
The present invention relates to compounds of the formula (X) which are useful innthe synthesis of pyrazolopyrimidinone compounds:n nwherein:n R 13 is C 1 to C 4 alkyl optionally substituted with one or two substituents selectednfrom OH, C 1 to C 4 alkoxy, benzyloxy, NR 5 R 6 , phenyl, furanyl and pyridinyl; C 3 to C 6 ncycloalkyl; 1-(C 1 to C4 alkyl)piperidinyl; tetrahydrofuranyl or tetrahydropyranyl; R 4 is SO 2 NR 7 R 8 ; R 5 and R 6 are each independently selected from H and C 1 to C 4 alkyl, or, together with thennitrogen atom to which they are attached, form a pyrrolidinyl, piperidinyl or morpholinylngroup; R 7 and R 8 , together with the nitrogen atom to which they are attached, form a 4-R 10 npiperazinyl group optionally substituted with one or two C 1 to C 4 alkyl groups andnoptionally in the form of its 4-N-oxide; R 10 is H; C 1 to C 4 alkyl optionally substituted with one or two substituents selected fromnOH, NR 5 R 6 , CONR 5 R 6 , phenyl optionally substituted with C 1 to C 4 alkoxy, benzodioxolylnand benzodioxanyl; C 3 to C 6 alkenyl; pyridinyl or pyrimidinyl; nor a salt of such compound, or an acid chloride derivative of such compound. |