| abstract |
Compounds of general formula (1) and pharmacologically acceptablensalts thereof:n n [wherein n R 1 represents a hydrogen atom, a halogen atom, an alkyl group or anhydroxyl group; n R 2 represents a hydrogen atom or a halogen atom; n R 3 represents a hydrogen atom, an alkyl group which may bensubstituted, an aralkyl group, an alkylcarbonyl group which may bensubstituted, an alkylsulfonyl group which may be substituted or the like; n each of R 4 and R 5 represents a hydrogen atom, a halogen atom, annalkyl group which may be substituted, a carbamoyl group or the like; n R 6 represents a heterocycle or the like; n each of R 7 and R 8 represents a hydrogen atom, an alkyl group or thenlike; n n represents 0, 1 or 2] n exhibit excellent activated blood coagulation factor X inhibitory activitynand are useful for the prevention or treatment of blood coagulation-relatedndiseases. |