http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1625117-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_26e19c12ac350fc1c0c02bcf301685e6 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-37 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D265-38 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D498-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D265-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-37 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D265-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-04 |
| filingDate | 2004-05-13^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2008-01-09^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_103af473ebe688d8acd0c8146eb1f1a5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e130ea5e2399a5616a9f2ca2ca194ee9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_74d15dde3ac31595e24483852997f1e1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2a0481cb83540cd27dca6939be425baf |
| publicationDate | 2008-01-09^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-1625117-B1 |
| titleOfInvention | Novel phenoxazinone derivatives as enzyme substrates and use thereof as indictor in the detection of microorganisms with peptidase activity |
| abstract | Chromogenic enzyme substrates that are 7-amino-phenoxazine derivatives (I) are new. Chromogenic enzyme substrates that are 7-amino-phenoxazine derivatives of formula (I). [Image] R 1and R 2hydrogen, 1-6C alkyl, halo, COOR', CONR'R'', sulfo, or sulfonamide, or together they complete a naphthalene ring or optionally substituted coumarin of formula (a); R 3and R 4hydrogen, halo, COOR', CONR'R'', sulfo or sulfonamide, or together complete a naphthalene ring of formula (b); R 5and R 6hydrogen, halo, COOR', CONR'R'' or 1-6C alkyl; R 7and R 8hydrogen, 1-6C alkyl, aralkyl, aryl, carboxyalkyl, carboxy or sulfo, or together complete a 4-6C ring; R 9hydrogen, bromo, chloro, benzoyl, carboxy or sulfo, but must be other than hydrogen if R 5is hydrogen; R' and R'' : hydrogen or 1-6C alkyl or together they complete a heterocycle containing one or more heteroatoms; A : at least one amino acid; X : blocking group or is absent; Provided that at least one of R 1/R 2and R 3/R 4forms a phenyl or optionally substituted coumarin ring, and when R 1/R 2form a coumarin ring, then R 3and R 4do not form a phenyl ring; R 6is hydrogen when R 1/R 2form a ring and is halo when R 1/R 2and R 3/R 4each form a benzene ring. [Image] [Image] Independent claims are also included for: (1) reaction medium that includes at least one (I), optionally also at least one other enzyme substrate (X) specific for an enzyme activity other than that detected by (I); (2) process for detecting, identifying and/or quantifying microorganisms that express at least one peptidase activity, using the medium of (1); (3) process for differentiating between Gram positive and negative bacteria, using a medium of (1) in which the (I) present includes an alanine residue; and (4) process for differentiating between Candida albicansand C. tropicalisor C. glabrata, using a medium of (1) in which the (I) present includes a proline residue. |
| priorityDate | 2003-05-13^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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