| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_046e16bd6918ef3cd62184605b15a413 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-07 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D333-36
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C227-32
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C227-08 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C229-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C229-34 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C227-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C227-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C227-32
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C229-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B53-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D333-36
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D333-22 |
| filingDate |
2004-09-17^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2010-01-13^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cf89e2bf52677b18b9f03e8139a4f199
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_62a7179752e6a2e0d5eed8c5c4c91e4c |
| publicationDate |
2010-01-13^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-1685092-B1 |
| titleOfInvention |
Asymmetric reductive amination of keto acid derivatives for producing amino acid derivatives |
| abstract |
The present invention relates to a process for producing amino acid derivatives such as optically active β-amino acid in short steps with good yield and high optical purity, which comprises reacting a keto acid of the formula (1): wherein R1 is hydrogen, an optionally substituted hydrocarbon, etc.; R2 is a spacer; and R3 is an optionally substituted alkoxy, etc., or a salt thereof, with ammonia or an amine or a salt thereof in the presence of a chiral catalyst and in the presence or absence of an acid and/or a fluorine-containing alcohol, to give an amino acid derivative of the formula (2): wherein Q is a group formed by removing one hydrogen atom from ammonia or an amine; X' is an acid and/or a fluorine-containing alcohol; and b is 0 or 1. |
| priorityDate |
2003-09-18^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |