| abstract |
The present invention relates to biaryl sulfonamides of the formula 1: wherein: R1 is H or Cl-.C6 a]kyl; R2 is H, C I -C6 alkyl, (CH2)nR2' , phenyl, or benzyl; n is 0-6; R2'is aryl, heteroaryl, cycloalkyl, or heterocycloalkyl; R 3 is, independently with respect to each occurrence, H, halogen, OC(halogen)3,C(halogen)3, alkoxy, or C I -C 6 alkyl; X is selected from CH20, OCH2, C (R3)=(R3)2-C(R3)2, CH2NHC(=O), O(C=O)NH, O, C(=O)CH2, SO2CH2C(=O)NH, SO2NH, OC(=O), CH2S(O), and CH2S(O)2; and Z is at least one aryl or heteroaryl moiety, and their use as for example metalloproteinase inhibitors. |